김학균 (Hark Kyun Kim, M.D.,Ph.D.)
- 국립암센터 항암신약신치료개발사업단 부단장
- 국립암센터 위암센터/희귀암클리닉 종양내과전문의
E-mail: hkim@ncc.re.kr
국립암센터 외래진료시간
- 월: 오전 (위암)
- 화: 오전 (위암)
- 수: 오전 (희귀암)
- 목: 오전 (위암)
(진료예약, 031-920-1000)
약력
- 1985.03 - 1991.02: 서울대학교 의과대학 학사
- 1996.03 - 2000.02: 서울대학교 의과대학 석박사
- 1994.05 - 1995.02: 서울대학교병원 인턴
- 1995.03 - 1999.02: 서울대학교병원 내과 레지던트
- 1999.03 - 2000.02: 서울대학교병원 혈액종양내과 전임의
- 2000.06 - 2001.05: 일본국립암센터 박사후연구원
- 2005.03 - 2009.12: 미국 National Cancer Institute 박사후연구원
- 2001.06 - 현재: 국립암센터
h-index 32
i10-index 52
최근 교신저자 논문
Jun Won Park, Min-Jung Seo, Kye Soo Cho, Myeong-Cherl Kook, Jong Min Jeong, Seul-Gi Roh, Soo Young Cho, Jae Hee Cheon, Hark Kyun Kim.
Smad4 and p53 synergize in suppressing autochthonous intestinal cancer.
Cancer Med 2022 May;11(9):1925-1936
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089223/
Jun Won Park, Jong Min Jeong, Kye Soo Cho, Soo Young Cho, Jae Hee Cheon, Dong Ho Choi, Sang Jae Park, Hark Kyun Kim.
MiR-30a and miR-200c differentiate cholangiocarcinomas from gastrointestinal cancer liver metastases.
PLoS One 2021 Apr 14;16(4):e0250083
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046207/
Hark Kyun Kim (corresponding author), Jeong Won Kang, Young‐Whan Park, Jung Young Kim, Minchae Kim, Soo Jin Kim, Se‐mi Kim, Keun Ho Ryu, Seonghae Yoon, Yun Kim, Joo‐Youn Cho, Keun Seok Lee, Tak Yun, Kiwon Kim, Mi Hyang Kwak, Tae‐Sung Kim, Jinsoo Chung, Joong‐Won Park.
Phase I and pharmacokinetic study of the vascular-disrupting agent CKD-516 (NOV120401) in patients with refractory solid tumors.
Pharmacol Res Perspect 2020 Apr;8(2):e00568 [link]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066534/
Dong-Gi Mun, Jinhyuk Bhin, Sangok Kim, Hyunwoo Kim, Jae Hun Jung, Yeonjoo Jung, Ye Eun Jang, Jong Moon Park, Hokeun Kim, Yeonhwa Jung, Hangyeore Lee, Jingi Bae, Seunghoon Back, Su-Jin Kim, Jieun Kim, Heejin Park, Honglan Li, Kyu-Baek Hwang, Young Soo Park, Jeong Hwan Yook, Byung Sik Kim, Sun Young Kwon, Seung Wan Ryu, Do Youn Park, Tae Yong Jeon, Dae Hwan Kim, Jae-Hyuck Lee, Sang-Uk Han, Kyu Sang Song, Dongmin Park, Jun Won Park, Henry Rodriguez, Jaesang Kim, Hookeun Lee, Kwang Pyo Kim, Eun Gyeong Yang, Hark Kyun Kim (corresponding author), Eunok Paek, Sanghyuk Lee, Sang-Won Lee, Daehee Hwang.
Proteogenomic characterization of human early-onset gastric cancer.
Cancer Cell 2019 Jan 14; 35:1:111:E10
https://www.cell.com/cancer-cell/fulltext/S1535-6108(18)30574-9
Sang-Jin Lee, Seung-Pil Shin, Seung Hee Lee, Jeong Won Kang, Myeong-Cherl Kook, In-Hoo Kim, Hark Kyun Kim.
Phase I trial of intravenous Ad5CRT in patients with liver metastasis of gastrointestinal cancers.
Cancer Gene Ther 2019 May;26(5-6):174-178
Hanna Yang, Dongwan Hong, Soo Young Cho, Young Soo Park, Woo Ri Ko, Ju Hee Kim, Hoon Hur, Jongkeun Lee, Su-Jin Kim, Sun Young Kwon, Jae-Hyuk Lee, Do Youn Park, Kyu Sang Song, Heekyung Chang, Min-Hee Ryu, Kye Soo Cho, Jeong Won Kang, Myeong-Cherl Kook, Nina Thiessen, An He, Andy Mungall, Sang-Uk Han, Hark Kyun Kim.
RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer.
Nat Commun 2018 Oct 25;9(1):4439
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202325/
Soo Young Cho, Jun Won Park, Yang Liu, Young Soo Park, Ju Hee Kim, Hanna Yang, Hyejin Um, Woo Ri Ko, Byung Il Lee, Sun Young Kwon, Seung Wan Ryu, Chae Hwa Kwon, Do Youn Park, Jae-Hyuk Lee, Sang Il Lee, Kyu Sang Song, Hoon Hur, Sang-Uk Han, Heekyung Chang, Su-Jin Kim, Byung-Sik Kim, Jeong-Hwan Yook, Moon-Won Yoo, Beom-Su Kim, In-Seob Lee, Myeong-Cherl Kook, Nina Thiessen, An He, Chip Stewart, Andrew Dunford, Jaegil Kim, Juliann Shih, Gordon Saksena, Andrew D Cherniack, Steven Schumacher, Amaro-Taylor Weiner, Mara Rosenberg, Gad Getz, Eun Gyeong Yang, Min-Hee Ryu, Adam J Bass, Hark Kyun Kim.
Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers.
Gastroenterology 2017 Aug;153(2):536-549.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863080/
Jun Won Park, Jung Min Park, Dong Min Park, Dae-Yong Kim, Hark Kyun Kim.
Sca-1 enriches for a cancer stem cell-like subpopulation in mouse gastric cancer.
Stem Cells 2016 May;34(5):1177-87.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.2329
Jun Won Park, Dong Min Park, Beom K Choi, Byoung S Kwon, Je Kyung Seong, Jeffrey E Green, Dae-Yong Kim, Hark Kyun Kim.
Establishment and characterization of metastatic gastric cancer cell lines from murine gastric adenocarcinoma lacking Smad4, p53, and E-cadherin.
Mol Carcinogenesis 2015 Nov;54(11)1521-7
Hark Kyun Kim, Jeffrey E. Green.
Review: Predictive biomarker candidates for the response of gastric cancer to targeted and cytotoxic agents.
Pharmacogenomics 2014;15(3):375-84.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670597/
Jun Won Park, Seok Hoon Jang, Dong Min Park, Na Jung Lim, Chuxia Deng, Dae Yong Kim, Jeffrey E. Green, Hark Kyun Kim.
Loss of E-cadherin and Smad4 cooperate to promote the development and metastasis of diffuse-type gastric adenocarcinoma.
Mol Cancer Res 2014 Aug;12(8):1088-99
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230498/
Seok Hoon Jang, Jun Won Park, Hyo Rim Kim, Je Kyung Seong, Hark Kyun Kim.
ADRM1 gene amplification is a candidate driver for metastatic gastric cancers.
Clin Exp Metastasis 2014 Aug;31(6):727-33
https://link.springer.com/article/10.1007/s10585-014-9663-4
Jun Won Park, Nam Suk Baek, Seok Cheol Lee, Su Jin Oh, Seok Hoon Jang, In Hoo Kim, Dae Yong Kim, Hark Kyun Kim.
Preclinical Efficacy Testing for Stomach and Liver Cancers using a Hollow Fiber Assay.
Cancer Res Treat 2014 Apr;46(2):186-93
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022828/
Gang Ahn, Dong Min Park, Jun Won Park, Joo-Youn Cho, Su-jin Rhee, Hyo-Young Kim, Dae-Seung Lee, In-Jin Jang, Hark Kyun Kim.
Development and validation of a microfluidic chip-based nano-liquid chromatography-triple quadrupole tandem mass spectrometry method for a sensitive and reliable quantification of 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma.
Anal Bioanal Chem 2013 Dec;405(30):9817-24
https://pubmed.ncbi.nlm.nih.gov/24126840/
등록특허
- 종양세포충실도 보정을 통한 현미부수체 불안정성의 판정방법 (등록특허10-2529641)
- 삼중사중극자 다중반응모니터링 기반 암표적치료제 효능예측 (등록특허10-2503069)
- 삼중사중극자 다중반응모니터링 기반 암표적치료제 효능예측 (등록특허10-2462097)
- Gastric cancer cell line derived from murine gastric adneocarcinoma lacking p53 and E-cadherin and use thereof (US15/011,124)
- 면역 치료 및 위암 치료제에 대한 효능 및 독성 평가를 위한 마우스 위암 세포주 (등록특허10-1456627)
- 마이크로RNA 프로파일을 이용한 간내 선암의 원발부위 예측방법 (등록특허10-2014-0066145)
- 지질 프로파일을 이용한 비소세포성 폐암의 조직학적 분류를 위한 정보를 제공하는 방법 (등록특허10-1384693)
- 인지질을 이용한 암의 진단 방법 (등록특허10-1389382)
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2014189203 - 질량분석패턴을 이용한 원발성간내담도암 및 전이성간암의 감별법 (등록특허10-1408217)